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50/50 is a 2011 comedy-drama film directed by Jonathan Levine, written by Will Reiser, starring Joseph Gordon-Levitt and Seth Rogen. The film is loosely inspired by Reiser's own experience with cancer.

Distributed by	Summit Entertainment (United States) Lionsgate (United Kingdom)
Release date(s)	September 30, 2011
Running time	100 minutes
Country	United States
Language	English
Budget	$8 million
Box office	$39,187,783

PLOT:-

Adam Lerner (Joseph Gordon-Levitt) is a 27-year-old public radio journalist with an artist girlfriend Rachael (Bryce Dallas Howard), of whom his best friend and co-worker Kyle (Seth Rogen) disapproves.
Adam discovers he has schwannoma neurofibrosarcoma (a malignant tumor) in his spine and must undergo chemotherapy. He sees on the Internet that his chances of survival are fifty-fifty. After Adam reveals his diagnosis, his overbearing mother, Diane (Anjelica Huston), who already cares for a husband suffering from dementia, wants to move in and care for him. Adam rejects this offer, however, as Rachael has promised to be the one to take care of him. However, Rachael is "uncomfortable" going into the hospital during Adam's chemo treatments. Later, Kyle sees Rachael kissing another man at an art gallery, and tells Adam that Rachael is cheating on him. Adam and Rachael break up. Throughout Adam's struggle, Kyle attempts to keep Adam's spirits high, which include helping Adam shave his head prior to chemotherapy and suggesting that Adam use his illness as a way to pick up women.

 Meanwhile, Adam skeptically begins going to a young and inexperienced therapist, Katherine McKay (Anna Kendrick), at the hospital. Although their relationship and sessions have a rocky start, he slowly begins to open up to her about his disease and how it is affecting him. The two develop a rapport both in and outside of their sessions, as the lines between doctor-patient and friends begins to blur. During chemo treatments, Adam also befriends Alan (Philip Baker Hall) and Mitch (Matt Frewer), two older cancer patients who are also undergoing chemotherapy.
After Mitch suddenly dies, Adam's fears become more evident upon hearing that his treatment is not working and that he needs to undertake a risky surgery as a last resort. The night before his surgery, Adam has an argument with Kyle and demands to drive Kyle's car because Kyle is drunk—even though Adam does not have a driver's license. After nearly causing an accident, Adam calls Katherine and tells her that he is tired and just wants it to be over. The next day Kyle drops Adam off at the hospital, where he undergoes his surgery. After the surgery, Kyle, Diane, and Katherine are told by the doctor that although the bone degradation was worse than they had thought, the tumor was successfully removed and Adam should recover.
The movie ends with Adam getting ready for a date, with Kyle encouraging him and cleaning the incision on Adam's back from the surgery. The doorbell rings and Adam lets Katherine inside as Kyle leaves. Katherine asks "Now what?", and Adam simply smiles.